Estimated read time: 5-6 minutes
This archived news story is available only for your personal, non-commercial use. Information in the story may be outdated or superseded by additional information. Reading or replaying the story in its archived form does not constitute a republication of the story.
ATLANTA — Poison control centers across the U.S. say they are seeing a steep increase in calls related to semaglutide, an injected medication used for diabetes and weight loss, with some people reporting symptoms related to accidental overdoses.
Some have even needed to be hospitalized for severe nausea, vomiting and stomach pain, but their cases seem to have resolved after they were given intravenous fluids and medications to control nausea.
From January through November, the America's Poison Centers reports nearly 3,000 calls involving semaglutide, an increase of more than 15-fold since 2019. In 94% of calls, this medication was the only substance reported.
In most of the calls, people reported dosing errors, said Dr. Kait Brown, clinical managing director of the association.
"Oftentimes, it's a person who maybe accidentally took a double dose or took the wrong dose," Brown said.
Compounded versions may require different doses
Semaglutide was approved by the FDA in 2017. It is sold as Ozempic when used for diabetes and Wegovy when used for weight loss. Even when used as directed by a doctor, people can have stomach and bowel side effects, including nausea, vomiting and constipation, especially when they start the drugs.
After demand overwhelmed supply, it went into shortage in the FDA's database in March 2022, which opened the door for certain qualified pharmacies to make compounded versions.
The compounded versions of semaglutide are often different from the patented drug. Many contain semaglutide salts called semaglutide sodium and semaglutide acetate. The FDA says the salt forms of the drug have not been tested and approved to be safe and effective the way the patented form of the medication has, and thus they don't qualify for the compounding exemption in the law for drugs in shortage. In other cases, the compounded versions are sold in unapproved dosages.
The FDA has sent letters to at least two online sellers warning them to stop. Drugmaker Novo Nordisk has sued to stop six medical spas, medical clinics and weight loss clinics from selling knock-off versions.
But these compounded versions are popular because they may cost less out-of-pocket, especially if the treatment isn't covered by insurance.
The FDA warned the public in June against taking compounded versions of the medication if the prescription forms were available. The agency said it had received adverse event reports after people used compounded versions of the drug.
Poison control centers say the reported symptoms don't allow them to know whether the calls stem from the patented drugs or the compounded versions, Brown said, but some state poison center directors say they believe that compounded versions are behind many of the calls.
Calls to poison centers increase
Dr. Joseph Lambson, director of the New Mexico Poison and Drug Information Center, detailed what happened to three people who called the Utah Poison Control hotline, which saw calls related to semaglutide nearly quadruple between 2021 and 2022. He wrote about the cases in the Journal of the American Pharmacy Association
Two of the callers had accidentally taken 10 times the standard dose of the drug.
"We were getting reports of people giving themselves doses we had never heard of before," Lambson said. "That's kind of what sparked our interest" in tracking the calls.
The brand name drugs are sold in pre-filled pens, which come with some safeguards. Patients dial to the correct dose and click to inject, so it's harder to make mistakes. Ordinarily, people start at lower doses and work up over time to the therapeutic amount so their bodies can adjust.
Compounded versions, however, typically come in multi-dose glass vials, and patients draw their own doses into syringes. It's easy to get confused.
"This is where we see a lot of errors. They end up drawing too much," Lambson said.
In a written statement, Novo Nordisk, the manufacturer of Ozempic and Wegovy, said patient safety is its top priority.
"We are taking multiple steps to ensure responsible use of our semaglutide medicines which are detailed on semaglutide.com," the statement said.
There's no specific antidote for a semaglutide overdose. The drug has a half-life of about a week, meaning it takes one week to clear half of it from your body. Emergency departments and hospitals can only help support patients with intravenous fluids and anti-nausea drugs as the drug works its way out out of their bodies.
In addition to nausea and vomiting, the Missouri Poison Center warns people who think they may have overdosed to watch for signs of low blood sugar, or hypoglycemia, which can be dangerous. Hypoglycemia is more common with semaglutide if you are also taking other medications for diabetes.
According to the Missouri Poison Center, signs of a semaglutide overdose include:
- Feeling lightheaded or dizzy;
- Feeling shaky or jittery;
- Sweating, chills and clamminess;
- Irritability or impatience;
- Headache;
- Weakness;
- Fatigue;
- Nausea and/or vomiting;
- Seizures;
- Confusion;
- Passing out;
If you think you have overdosed on a weight loss drug, Brown said the best thing to do is call your local poison control center or the national hotline at 800-222-1222.
"That way, one of the specialists will be able to take specific information to their case regarding how much they administered, the type of overdose they're experiencing … and decide if they're safe to stay at home or if they are going to need to seek medical attention, especially if they've developed symptoms," Brown said.
