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SANTA CLARA, Calif. (AP) — The Philadelphia Eagles did things in reverse and got burned.

After falling behind by double-digits in winning each of their first three games, the Eagles grabbed a 21-10 lead before losing to the 49ers 26-21.

Colin Kaepernick tossed TD passes of 55 yards to Frank Gore and 12 yards to Stevie Johnson. Phil Dawson hit four field goals, including a go-ahead, 46-yard kick in the third quarter.

The Eagles generated little offense against San Francisco, getting just 22 of their 213 yards on the ground. Philadelphia's three touchdowns came on a blocked punt, Malcolm Jenkin's 53-yard interception return and Darren Sproles' 82-yard punt return.

The 2-2 Niners also intercepted Nick Foles twice and held him to 195 passing yards.

BALTIMORE (AP) — Steve Smith had a pretty good afternoon against his former team.

The former Panthers wide receiver grabbed seven passes for 139 yards and two touchdowns to lead the Ravens' 38-10 rout of Carolina in Baltimore. Smith scored twice in the second quarter to help the Ravens carry a 21-7 lead into halftime.

Smith spent 13 seasons with Carolina before he was released in a cost-cutting move last offseason.

Joe Flacco went 22 of 31 for 327 yards and three touchdowns as Baltimore won its third straight since a season-opening loss to Cincinnati.

Cam Newton completed just 14 of 25 passes and finished with 197 yards for the 2-2 Panthers.

CHICAGO (AP) — The Packers went into Chicago and promptly gave up a touchdown on the first series before Aaron Rodgers threw for 302 yards and four TDs in Green Bay's 38-17 rout of the Bears.

The 2-2 Packers scored on their first six possessions and racked up 358 yards after being held to 223 in last Sunday's loss to Detroit.

Green Bay also intercepted Jay Cutler twice in the third quarter and won at Soldier Field for the fifth straight time.

The Bears fell to 2-2

EAST RUTHERFORD, N.J. (AP) — The New York Jets lost to an NFC North team for the third straight week. The Detroit Lions lead that division at 3-1 after Matthew Stafford threw for two touchdowns and ran for another in a 24-17 win at the Meadowlands. Stafford finished 24 of 34 for 293 yards while Lions No. 1 receiver Calvin Johnson sat out most of the game with an injured ankle.

Jeremy Ross and Eric Ebron caught scoring passes for the Lions, who also opened 3-1 last season before missing the playoffs.

Jets quarterback Geno Smith completed just six of his first 15 passes, threw an interception and lost a fumble. He finished 17 of 33 for 209 yards and a touchdown amid chants of "We Want Vick!" wafting through the Meadowlands.

INDIANAPOLIS (AP) — Reggie Wayne moved up the NFL all-time lists in receptions and receiving yards while helping the Indianapolis Colts hammer Tennessee 41-17. Playing in his 200th game, the 35-year-old Wayne had seven receptions for a season-high 119 yards and his first TD of the season. He passed Isaac Bruce for seventh on the NFL's career receptions list, Henry Ellard for 10th in career yards receiving and extended his NFL record for consecutive games with three or more catches to 75.

Wayne couldn't have done it without Andrew Luck, who threw for a season-best 393 yards and four touchdowns in the Colts' ninth straight win over AFC South opponents.

T.Y. Hilton had six catches for 105 yards for the 2-2 Colts.

Charlie Whitehurst finished 12 of 23 for 177 yards with one TD and one interception for the 1-3 Titans. He started in place of Jake Locker, who sat out with a right wrist injury.

SAN DIEGO (AP) — Blake Bortels played quite well in his first NFL start, but Philip Rivers was better.

Rivers had 377 passing yards and threw two of his three scoring passes to Eddie Royal as the San Diego Chargers downed Jacksonville 33-14. Royal had five catches for 105 yards, including scoring grabs of 47 and 43 yards.

Bortles was picked off twice while completing 29 of his 37 passes for 253 yards and a touchdown. He couldn't prevent the Jags from their fifth straight double-digit loss since last season's final.

The Chargers have won three straight since a season-opening loss to Arizona.

The Jaguars are 0-4.

MINNEAPOLIS (AP) — Teddy Bridgewater is undefeated as an NFL starting quarterback.

Bridgewater was 19 of 30 for 317 yards, no touchdowns and no interceptions in his first career start as Minnesota outscored Atlanta 41-28. He also ran for a 13-yard touchdown late in the first half to put the Vikings ahead to stay.

The Vikings moved the ball downfield all afternoon with their first-round pick at the helm. Matt Asiata (a-zee-AH'-tah) had scoring runs of 6, 3 and 1 yards while compiling 78 yards on 20 carries. Jerick McKinnon actually led Minnesota's ground game with 135 yards on 18 carries, making Vikings fans miss Adrian Peterson less and less.

Matt Ryan had three more scoring passes but was intercepted twice while going 25 for 41 for 298 yards.

Both teams are 2-2.

PITTSBURGH (AP) — Tampa Bay has its first victory of the season.

Mike Glennon hit a diving Vincent Jackson for a 5-yard touchdown with seven seconds remaining to lift the Buccaneers over the Steelers 27-24 in Pittsburgh. Glennon passed for 302 yards in his first start of the season, including a 41-yard catch-and-run by Louis Murphy that set up Jackson's score.

The Bucs blew an early 10-0 lead, but the Steelers committed 13 penalties for 125 yards and let Tampa Bay stay close.

Ben Roethlisberger (RAWTH'-lis-bur-gur) passed for 314 yards and three touchdowns for the 2-2 Steelers, who couldn't protect a seven-point lead in the fourth quarter.

HOUSTON (AP) — The Houston Texans already have topped last season's win total, with help from another J.J. Watt touchdown.

Watt returned an interception 80 yards for a touchdown to put the Texans ahead 14-10 in the third quarter of a 23-17 win over Buffalo. The defensive end has scored two TDs for the 3-1 Texans this season, more than running back Arian Foster and receiver Andre Johnson combined.

Watt's TD came after Ryan Fitzpatrick threw his second interception against his former team. Fitzpatrick finished with 268 passing yards, including a 35-yard scoring strike to DeAndre Hopkins just before halftime.

EJ Manuel finished with 225 yards passing, two touchdowns and two interceptions for the 2-2 Bills. He was driving late when Darryl Morris picked him off at the Houston 15 to secure the victory.

LONDON (AP) — It turns out the Oakland Raiders can't win in Europe, either.

The Raiders are 0-4 after Ryan Tannehill torched them for 278 yards and two touchdowns in Miami's 38-14 rout of Oakland in London.

Tannehill threw a 13-yard touchdown to Mike Wallace and an 18-yarder to Dion Sims. Lamar Miller rushed for two more TDs and cornerback Cortland Finnegan ran back a fumble 50 yards for another to help the 2-2 Dolphins end a two-game losing streak.

The Raiders finished the game with Matt McGloin under center after Derek Carr was injured in the third quarter. Carr threw a short TD pass on Oakland's first drive, but the Raiders didn't score again until midway through the final period.

The Raiders are averaging just 13 points a game this season.

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