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LOUISVILLE, Ky. (AP) — Trevor Lawrence overcome two early interceptions to throw three touchdown passes, Travis Etienne rushed for 192 yards and a score and No. 3 Clemson routed Louisville 45-10 for its 22nd consecutive victory. Darien Rencher and Chez Mellusi added rushing TDs for the Tigers, who missed first-quarter chances to build a big lead when Lawrence was picked off twice near the goal line. The sophomore quarterback settled down to hit Joseph Ngata and Justyn Ross with second-quarter TDs for a 17-3 lead.

BLACKSBURG, Va. (AP) — Quincy Patterson, who came off the bench in the second half, rushed for 122 yards and ran in a conversion in the sixth overtime to give the Hokies a historic victory

WINSTON-SALEM, N.C. (AP) — Nick Sciba kicked a 25-yard field goal _ his school-record-tying fifth of the game _ with 4:18 remaining, and Wake Forest beat Florida State 22-20. Cade Carney had a 3-yard touchdown run and Sam Hartman was 21 of 38 for 308 yards in his first start of the season. The Demon Deacons won a game that had three lead changes in the fourth quarter, snapped a seven-game losing streak in the series and bounced back from their record-setting 62-59 loss to Louisville.

CHARLOTTESVILLE, Va. (AP) — Bryce Perkins ran for three touchdowns and Wayne Taulapapa ran for two as Virginia beat Duke for the fifth year in a row, 48-14. The Cavaliers forced five turnovers in the key Coastal Division matchup and turned them into 20 points. Joe Reed also returned a kickoff 95 yards for a touchdown. It was his second kickoff return touchdown this season and program-record fifth of his career.

MIAMI GARDENS, Fla. (AP) — Antwan Owens blocked a Miami chip-shot field goal in the final seconds of regulation, Jordan Mason scored on a 1-yard rush on the first possession of overtime and Georgia Tech knocked off the Hurricanes 28-21. Miami missed three field goals in the game. Georgia Tech got touchdowns on a fumble recovery and pass by punter Pressley Harvin III on a fake in the second quarter.

BOSTON (AP) — AJ Dillon ran for 223 yards and three touchdowns, David Bailey had two long TD runs with 181 yards and Boston College pounded the Atlantic Coast Conference's top rushing defense in a 45-24 victory over North Carolina State. Dillon had scores of 2, 3 and 8 yards as the Eagles ran for 429 yards on 60 attempts. Dennis Grosel completed 6 of 15 passes for 103 yards in his first collegiate start for BC.

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