Recent surveys show the top reasons people have hesitancy about receiving the COVID-19 vaccine is because:
A—They believe the trials were rushed.
B—They would rather wait until others receive it before they make a decision (you go before I go).
Both positions have merit. So, first, let's talk about the 118,000-plus trial participants who volunteered for vaccine testing.
Let's start with Pfizer
For its vaccine, 44,000-plus volunteers participated. Half received the vaccine, and the other half were given a placebo. All were told to go about their lives. During the trials, 162 of the estimated 22,000 placebo recipients contracted the coronavirus, while only eight of the other 22,000 vaccine recipients tested positive for COVID-19.
Of the 162 infected, nine became severely ill with symptoms, while only one of the eight vaccine recipients did. This led to the results that the Pfizer vaccine was found to be 95% effective at reducing disease and life-threatening symptoms. Think about those odds knowing there are 7.6 billion people on this planet and you're one of them.
Details: Requires two shots with 21 days in between receiving them, followed by a 14-day period after the second shot to reach full immunity.
Next up: Moderna
For its trials, 30,000 participants were also submitted to the 1:1 ratio testing. Of the placebo group, 196 contracted COVID-19 with 30 cases being severe. Only 11 contracted the virus in the vaccine group with zero showing severe symptoms. Both of these trials included participants ranging in ages from 18-71+ and from diverse communities including Hispanic, LatinX, Black or African American, Asian American, Multiracial, and Caucasian. Again, these numbers indicated a high 94.1% efficacy rate in preventing disease and hospital-grade symptoms or death.
Details: Requires two shots with 28 days in between receiving them, followed by a 14-day period after the second shot to reach full immunity.
The latest from Johnson & Johnson
Johnson & Johnson's trials also conducted ratio testing for 43,700-plus participants of various age groups and ethnicities. What's different is 41% of the participants had pre-existing conditions such as obesity, Type 2 diabetes, hypertension, HIV, and other immune compromises. This is important because COVID-19 symptoms can be worse for people who have these at-risk conditions.
Another difference with Johnson & Johnson is that unlike Pfizer and Moderna vaccines that have to be kept at extremely low temperatures and require two inoculations for effectiveness, J&J only requires one dose and can be stored safely at more regulated refrigeration for up to three months. As for the results, the vaccine provided 66% effectiveness at preventing moderate to severe symptoms, 28 days after the vaccination, but demonstrated 85% protection against hospitalization and death after day 28.
Details: One vaccination with full efficacy after 28 days.
As for the trials being rushed
Typical vaccine developments and trials in a non-pandemic world require three main things: Resources, money, and approvals.
Normally vaccines can take years to develop because they often run low on the first and second or can get tied up in long lines waiting for approvals from the Food and Drug Administration and similar government agencies that have other vaccines and drugs in the queue being reviewed for approval.
When the pandemic hit, the world put everything else on hold. Scientists came together to work on this sole solution and governments, pharmaceutical companies, private donors, and citizens came together to make sure funding was not an issue. So, with these vaccines prioritized and all-hands-on-deck with unlimited money and resources, they were able to be developed faster, but no steps were skipped. They were merely streamlined.
As of Feb. 12, 2021: more than 46 million people had received the vaccine in the United States.