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Botched drug trial...Graham backs Bush...Rough seas hamper search

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PARIS (AP) — A doctor in France says three of the six men who have been hospitalized after a botched clinical drug trial could have "irreversible" brain damage. Doctors say there's no known antidote to the experimental drug they were testing. The country's health minister says all of the medical volunteers who've been hospitalized were healthy men when the trial began on Jan. 7. In all, 90 volunteers were given the experimental drug as part of a test of a new painkiller compound. Prosecutors have opened an investigation.

NORTH CHARLESTON, S.C. (AP) — Lindsey Graham says he doesn't have any doubt that Jeb Bush would be ready "to be commander-in-chief on day one." The South Carolina senator today announced that he's backing the former Florida governor for the Republican presidential nomination. Graham ended his own campaign last month after failing to pick up much support -- but his endorsement is considered valuable ahead of the early South Carolina primary.

HONOLULU (AP) — The surf is choppy off the coast of the Hawaiian island of Oahu (oh-AH'-hoo), and that's hampering the search for the 12 crew members who were on two Marine helicopters that collided overnight, about two and a-half miles offshore. Searchers have spotted a debris field spanning about two miles. The Coast Guard is leading the search, coordinating with some Navy and Air Force aircraft.

JAKARTA, Indonesia (AP) — Police in Indonesia say yesterday's attack by suicide bombers in the heart of the country's capital was funded by the Islamic State group. They've seized an Islamic State flag from the home of one of the attackers. And they've carried out raids across the country in which one suspected militant was killed.

MUNFORD, Tenn. (AP) — Is it really a winner? A Tennessee man this morning pulled a folded Powerball ticket from the front pocket of his shirt, and told the "Today" show audience on NBC that he had one of the three winning tickets from Wednesday night's $1.6 billion Powerball jackpot. John Robinson appeared alongside his wife, his attorney and his daughter. The Robinsons said the attorney advised them to go on national TV first, to go public while still controlling the story. Their claim hasn't yet been verified.

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