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Type 1 diabetic women should be targeted for osteoporosis screening and possible fracture prevention as they transition through menopause.
Scientists in the United States conducted a study "to determine whether middle-aged premenopausal women with type 1 diabetes had more self-reported fractures and lower bone mineral density (BMD) compared with nondiabetic women."
"Participants were premenopausal women aged 35-55 years with type 1 diabetes (ng; 32.2±5.3 years duration) and without diabetes (n#7)," noted E.S. Strotmeyer and colleagues of the University of Pittsburgh. "Total hip, femoral neck, whole-body, and spine BMD were measured by dual X-ray absorptiometry. Calcaneal broadband ultrasound attenuation (BUA) was assessed with quantitative ultrasound.
The researchers determined, "Women with type 1 diabetes were more likely to report a fracture after age 20 years compared with nondiabetic women (33.3 vs. 22.6%; age-adjusted odds ratio 1.89 [95% CI 1.02 -3.49]). Type 1 diabetes was associated with lower total hip BMD (0.890 vs. 0.961 g/cm2; p2; p=0.001), whole-body BMD (1.132 vs. 1.165 g/cm2; p<0.01), and lower calcaneal BUA (71.6 vs. 84.9 dB/MHz; p<0.001) after multivariate adjustment. BMD was 3-8% lower in type 1 diabetic compared with control women and calcaneal BUA was 15% lower."
"Spine BMD and biomarkers of bone remodeling were not significantly different between groups," continued the authors. "In the type 1 diabetic women, reduced monofilament detection and blindness were both associated with lower BMD."
The investigators concluded, "Lower BMD in premenopausal women with type 1 diabetes may substantially increase their risk of developing osteoporosis after menopause. Type 1 diabetic women should be targeted for osteoporosis screening and possible fracture prevention as they transition through menopause."
Strotmeyer and colleagues published their study in Diabetes Care (Middle-aged premenopausal women with type 1 diabetes have lower bone mineral density and calcaneal quantitative ultrasound than nondiabetic women. Diabetes Care, 2006;29(2):306-311).
For additional information, contact E.S. Strotmeyer, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 North Bellefield Ave., Room 519, Pittsburgh, PA 15213, USA; E-mail: strotmeyere@edc.pitt.edu
The publisher's contact information for the journal Diabetes Care is: American Diabetes Association, 1701 N Beauregard Street, Alexandria, VA 22311-1717, USA.
Keywords: Pittsburgh, Pennsylvania, United States, Diabetes, Menopause, Osteoporosis, Osteoporosis Risk Factor, Body Mass Index, Type 1 Diabetes, Women's Health.
This article was prepared by Biotech Week editors from staff and other reports. Copyright 2006, Biotech Week via NewsRx.com.
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