Germany's Merck acquires Silence Therapeutics in $1.3 billion RNA drug deal

Oct 19 — German drugmaker Merck KGaA said on Monday it would acquire UK-based Silence ​Therapeutics in an all-cash deal for about $1.3 billion, bolstering its pipeline of targeted medicines and adding RNA-targeting drug technology.

Merck ‌will pay $20 per American depositary share for Silence, representing a premium of 130% to the ⁠stock's last close. US-listed shares ​of Silence more than doubled in ⁠premarket trading.

The deal broadens Merck KGaA's gene-silencing capabilities by adding ‌Silence's siRNA medicines, which ‌work by switching off disease-related gene messages before they ⁠can produce harmful proteins.

This is Merck ⁠KGaA's third major acquisition in less than two years, following its $3.9 billion purchase of SpringWorks Therapeutics in 2025 and its pending $11.3 billion takeover of life-sciences tools maker Bio-Techne.

Silence's lead therapy candidate, divesiran, is set to enter late-stage trials for phlebotomy-dependent polycythemia vera, ‌a rare blood cancer in which the bone ​marrow produces too many red blood cells.

Patients with this condition require regular therapeutic blood draws, known as phlebotomies, to manage their red blood cell levels.

In August, the company reported positive mid-stage trial data for divesiran showing the drug significantly reduced the need for the blood-removal procedures and helped keep patients' blood thickness under ​control.

Silence is also developing the therapy zerlasiran for people at risk ‌of heart disease because ‌of ⁠high levels of lipoprotein(a), a blood protein linked to cardiovascular disease, as well as earlier-stage treatments for high cholesterol, obesity and diseases caused by an overactive immune response.

The deal is expected to close in ‌the first quarter of ​2027. The companies said the transaction will ‌be effected through ⁠a UK scheme ​of arrangement.

(Reporting by Christy Santhosh in Bengaluru; Editing by Devika Syamnath and ​Maju Samuel)

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