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Barbara Novack (Renee Zellweger) hits New York City with her new book DOWN WITH LOVE, a pre-feminist manifesto on saying no to love and yes to career, empowerment - and sex.As Barbara's revolutionary tome rockets to the top of the best-seller charts, she becomes the target of ace journalist Catcher "Catch" Block (Ewan McGregor), ladies man/ man's man/ man about town, who is determined to take her down. Cath's best friendand boss, the neurotic and love sick Peter McMannus (David Hyde Pierce), tries to rein in his star writer, while haplessly pursuing the object of h8s affections, Vikki Hiller (Sara Paulson) Barbara's brilliant and feisty editor. Vikki plays tough in a man's world, which includes her old boss Theodore Banner (Tony Randall).