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NEW YORK (AP) — Aaron Harang threw no-hit ball for seven innings but was pulled after 121 pitches, and reliever Luis Avilan gave up David Wright's two-out single in the eighth as the Atlanta Braves beat the New York Mets 6-0 Friday night.

As Harang's pitch count increased on a chilly evening, it seemed doubtful manager Fredi Gonzalez would let him go the distance. Harang worked around six walks, including two in the sixth inning and another pair in the seventh.

Harang (3-1) left for a pinch hitter during a long, four-run eighth. He was never in the on-deck circle — the decision had already been made that he was done.

Jordan Walden completed the combined one-hitter.

The Mets hit few balls hard against the resurgent Harang, who lowered his ERA to an NL-best 0.70 ERA. The closest they came to a hit off the 35-year-old right-hander was actually on a check-swing tapper by Travis d'Arnaud in the second inning.

Jonathan Niese (0-2) took the loss.

BREWERS 5, PIRATES 3

PITTSBURGH (AP) — Kyle Lohse pitched effectively into the seventh inning and Carlos Gomez homered to lead Milwaukee past Pittsburgh.

Lohse (3-1) improved to 11-2 in his career against the Pirates, allowing one earned run in a win against them for the second time in six days.

He fell one out shy of a complete game Sunday at Miller Park. This time, he was charged with three runs — two unearned — and four hits with three walks with five strikeouts.

Gomez homered deep to center to lead off the fifth and added an RBI single an inning later as the Brewers rallied from two runs down.

Charlie Morton (0-2) allowed five runs and eight hits in six innings while losing to Lohse for the second time this week. Russell Martin had two hits and two RBIs for the Pirates, who have lost six of eight.

REDS 4, CUBS 1

CHICAGO (AP) — Alfredo Simon lowered his ERA to 0.86, and Cincinnati won for the 16th time in its last 17 games at Wrigley Field.

Making his third start, Simon (2-1) allowed an unearned run in six-plus innings and sent the Cubs to their fifth straight loss. Jonathan Broxton pitched a hitless ninth for his second save, completing a six-hitter as the Reds stretched their winning streak to a season-best three.

Jeff Samardzija (0-2) gave up three runs — one earned — and six hits in seven innings with seven strikeouts and two walks.

DIAMONDBACKS 4, DODGERS 2, 12 INNINGS.

LOS ANGELES (AP) — Aaron Hill hit a two-run single in the 12th inning and Miguel Montero homered to lead Arizona past Los Angeles.

The Diamondbacks snapped a six-game losing streak and improved to 5-14, the worst record in the majors. To do it, they had to overcome Juan Uribe's tying homer in the ninth off closer Addison Reed.

Chris Perez (0-1) gave up a leadoff double to A.J. Pollock in the 12th and plunked pinch-hitter Cliff Pennington on the left foot as he squared to bunt. Gerardo Parra advanced the runners with a sacrifice, and Hill's liner to right-center broke the tie.

Joe Thatcher (0-1) pitched 1 1-3 scoreless innings for the victory and Trevor Cahill got three outs for his first major league save. Cahill was 0-4 with a 9.17 ERA in four starts before he was demoted to the bullpen.

NATIONALS 3, CARDINALS 1

WASHINGTON (AP) — Cardinals catcher Yadier Molina's throwing error combined with Michael Wacha's wild pitch to allow two unearned runs in the seventh inning, breaking a tie and helping Gio Gonzalez and Washington get the win.

Gonzalez (3-1) allowed one run and four hits in seven innings, retiring the last 11 batters he faced. He finished with seven strikeouts and one walk as Washington ended an eight-game losing streak against St. Louis that dated to Game 5 of the teams' 2012 NL division series.

Wacha (2-1) gave up five hits and one earned run. But a night after the Nationals made three errors — they initially were charged with four, but one was changed to a hit Friday — it was the Cardinals' turn to be sloppy.

PADRES 2, GIANTS 1

SAN DIEGO (AP) — Tyson Ross held the San Francisco Giants to four hits and struck out nine in eight scoreless innings, and San Diego handed Matt Cain his third straight loss.

Ross (2-2) beat Cain five days after topping AL Cy Young Award winner Max Scherzer and the Detroit Tigers. The right-hander was rarely in trouble, other than allowing a leadoff double to Angel Pagan. Ross then retired the next eight batters. He walked one.

Pablo Sandoval was the only Giants runner to reach third base, after hitting a single leading off the seventh and advancing on a walk and a double-play ball. He was stranded when Ross got Brandon Crawford to line to shortstop.

Cain (0-3) allowed four hits and one unearned run in seven innings while striking out eight and walking two.

ROCKIES 12, PHILLIES 1

DENVER (AP) — Troy Tulowitzki hit a three-run homer after No. 3 hitter Carlos Gonzalez was intentionally walked in front of him, Tyler Chatwood pitched seven strong innings for his first win of the season, and Colorado routed Philadelphia.

Tulowitzki went 3 for 3 on the night, drove in five runs and drew a key walk during the Rockies' four-run first inning. Drew Stubbs and Charlie Blackmon added three hits apiece. The 18 hits represented a season high for the Rockies and their run total matched a season high.

Chatwood (1-0), who missed the first two weeks of the season with a left hamstring strain, allowed one unearned run on two hits in his second start of the season and first at home.

Phillies starter Jonathan Pettibone (0-1) went four innings and allowed eight runs on nine hits.

___

INTERLEAGUE

MARLINS 8, MARINERS 4

MIAMI (AP) — Giancarlo Stanton hit a grand slam with none out in the ninth inning, and Miami took advantage of an overturned call on a replay review to beat Seattle.

Reed Johnson was called out on a force play following a bunt, but the umpires reviewed the ruling and determined third baseman Kyle Seager had juggled the ball. The Mariners then deployed five infielders, and Stanton cleared them all with a towering homer to the left of the home-run sculpture.

Johnson singled to start the ninth against Yoervis Medina (0-1), and Christian Yelich beat out a bunt for his third hit. Marcell Ozuna's bunt loaded the bases following the replay review, and Stanton hit his sixth homer on a 1-2 count.

Stanton had five RBIs to increase his total to 26, most in the majors.

Steve Cishek (1-0) pitched a perfect ninth.

Copyright © The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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